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System Requirements
OS Windows 7 or later
macOS 10.10 or later
Fedora Linux 21 or later
Red Hat Linux 7.2 or later
Ubuntu Linux 14.04 or later
Memory1 GB RAM
Hard Disk250 MB available disk space
Display1024 x 768 or higher resolution

Changes in version 4.2.4 (Aug 17, 2018)


  • Increased the maximum allowed primer length to 250 bases.
    (Requested by Eduardo Rodenas Martinez)
  • Dramatically sped up opening of large FASTQ files.
    (Requested by Alfonso Valencia)
  • Enhanced the "Make Protein" converter to transfer DNA colors to the protein sequence.
    (Requested by Luca Jovine)
  • Allowed protein_bind features to be bidirectional.
  • Provided the option, when using Folders view in a collection, to rename a selected file or folder by tapping Enter/Return on macOS or F2 on Windows.
  • Enabled import from NCBI of the reverse complement of a range of bases by specifying the right endpoint first.
  • Enhanced the multiple alignment tool to accept sequence traces as input.
  • Ensured that the Find bar and search results remain visible when switching to another sequence file in a collection and then back.
  • Updated the common features database.
  • Updated MAFFT from 7.312 to 7.407.
  • Made various color, textual, and other visual enhancements.


  • Improved network communication on Windows.
    (Reported by F. Javier Piedrafita and others)
  • Fixed an issue where changing the name of a new DNA or protein file after pasting in a GenBank or GenPept sequence resulted in all features being lost.
    (Reported by C. Dustin Rubinstein)
  • Fixed numerous issues with using proper group and decimal separators for European users.
    (Reported by Thomas Reinard)
  • Improved the import of primers copied to the clipboard from programs such as Excel.
    (Requested by Leah Tait and others)
  • Fixed an issue that resulted in content in the Description Panel not being visible or displaying the wrong font.
    (Reported by Peter Nguyen, Pratyush Routray, and Cole Peters)
  • Improved the editing of custom common features.
    (Reported by Shahar Bracha)
  • Improved stability when running SnapGene on a case-sensitive APFS file system.
    (Reported by Jason Eads and Unekwu Yakubu)
  • Improved the decoding of features in Geneious files.
    (Reported by Christine Eyler)
  • Prevented duplicate annotations that could occur when detecting common features.
    (Reported by Wulf-Dirk Leuschner)
  • Prevented false positives when searching a collection by sequence name.
    (Reported by Melissa Stokes)
  • Enabled the pasting into various controls of text that begins with "<" and ends with ">".
    (Reported by Wulf Dirk Leuschner)
  • Modified the feature translation context menu to include a command for adjusting feature translation options rather than generic translation options.
    (Reported by Chris Tipper)
  • Restored the NEB "2-Log DNA Ladder", which is identical to the newly renamed "1 kb Plus DNA Ladder".
    (Requested by multiple confused scientists)
  • Improved stability when running Clustal Omega on some Windows installations.
    (Reported by Yaseen Mamoori)
  • Corrected a regression that resulted in the font size being too large when printing.
    (Reported by Tausif Alam and others)
  • Corrected a regression with copying from SnapGene and pasting into programs such as Excel.
    (Reported by Leah Tait and others)
  • Ensured that the default directory for opening/saving/exporting is shown by default.
  • Improved the opening of RTF-encoded files.
  • Improved the warning system for shared licenses when the application has been idle for an extended period of time.
  • Prevented the selection (or selection bar) from being cleared inappropriately when editing a multiple alignment.
  • Improved stability when deleting residues within a multiple alignment.
  • Ensured that the selection bar is empty when a single row of gaps is selected in a multiple alignment.
  • Ensured that clicking the symbols button consistently pops up a dialog on Windows.
  • Prohibited renaming a folder in a collection to include a forbidden directory separator.
  • Fixed an issue with computing alignments with Clustal Omega, MUSCLE, and T-Coffee on Windows while logged in with a username that contains Unicode characters.
  • Ensured that when a DNA sequence is modified so that the number of feature segments drops to one, the remaining segment name is cleared.
  • Fixed an issue where -'s were shown when line breaking text in some places in the Japanese translation.
  • Improved the computation of sequence-profile alignments with MAFFT.
  • Fixed various issues with renaming a folder in a collection and then maintaining focus or retaining the selection.
  • Improved the behavior when using Find in Features view.
  • Ensured that features are consistently the appropriate height in circular maps.
  • Ensured that an amino acid name is displayed in Sequence view when a codon spans two adjacent translated features.
  • Improved stability when opening certain files.
  • Corrected the "Go To" dialog to show a blinking cursor instead of "1" when first opened.
  • Improved the behavior when creating or choosing a new Main Collection on Windows.
  • Fixed an isolated pliancy issue on macOS with Features and Primers views.
  • Corrected the behavior when Cmd/Ctrl-clicking feature names in Features view.
  • Ensured robust alignments with T-Coffee when the user account has spaces in the username.

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